mif as cardiac-derived myocardial depressant factor

mif as cardiac-derived myocardial depressant factor

  • macrophage migration inhibitory factor is a cardiac

    Macrophage migration inhibitory factor is a cardiac

    Macrophage migration inhibitory factor (MIF) is a pluripotent proinflammatory cytokine that is ubiquitously expressed in organs, including the heart. However, no specific role for MIF in modulating cardiac performance has yet been described.

  • method of treatment and bioassay involving macrophage

    Method of Treatment and Bioassay Involving Macrophage

    Other aspects of the invention relate to macrophage migration inhibitory factor (MIF) as a myocardial depressant factor and as a mediator of endotoxin-induced cardiac dysfunction in vivo.

  • endotoxin-induced myocardial dysfunction | circulation

    Endotoxin-Induced Myocardial Dysfunction | Circulation

    The pathophysiology of sepsis-induced myocardial dysfunction still remains controversial. Macrophage migration inhibitory factor (MIF) has recently been identified as a cardiac-derived myocardial d...

  • the pathophysiologic role of myocardial depressant factor

    The pathophysiologic role of myocardial depressant factor

    Myocardial Depressant Factor (MDF) is a small peptide circulating in the blood of all mammalian species tested in a variety of shock states including endotoxic, hemorrhagic, cardiogenic, bowel ischemic, acute pancreatitis, burn, and traumatic shock. MDF is produced by the action of proteolytic enzymes released by the ischemic pancreas.

  • myocardial depressant factor

    Myocardial depressant factor

    Myocardial depressant factor (MDF) or Myocardial Toxic factor (MTF) is a low-molecular-weight peptide released from the pancreas into the blood in mammals during various shock states.. MDF is a significant mediator of shock pathophysiology, reducing myocardial contractility, constricting splanchnic arteries and impairing phagocytosis by the reticuloendothelial system.

  • hyperglycemic myocardial damage is mediated by

    Hyperglycemic Myocardial Damage Is Mediated by

    MIF also induced the expression of matrix metalloproteinase (MMP9) which is involved in remodeling[8]. A recent report indicate that MIF mediates late cardiac dysfunction after burn injury[9]. Furthermore, MIF has been considered a cardiac-derived myocardial depressant factor[10]. Previous in vitro studies

  • (pdf) macrophage migration inhibitory factor mediates late

    (PDF) Macrophage migration inhibitory factor mediates late

    demonstrated that macrophage migration inhibitory factor (MIF) is a myocardial depressant protein and that MIF mediates late, prolonged cardiac dysfunction after endotoxin challenge in mice.

  • macrophage migration inhibitory factor in myocardial

    Macrophage migration inhibitory factor in myocardial

    May 01, 2014· Acute myocardial infarction (AMI) remains one of the leading causes of death in the developed world. There is emerging evidence that the cytokine macrophage migration inhibitory factor (MIF) is a crucial player in AMI.

  • high glucose induces apoptosis in ac16 human

    High glucose induces apoptosis in AC16 human

    Diabetes mellitus and cardiovascular disease are associated with the inflammatory state in the presence of the abnormal expression of pro‐inflammatory mediators such as interleukin (IL)‐1, IL‐18 and tumour necrosis factor (TNF)‐α. 9-11 Recently, macrophage migration inhibitory factor (MIF) was identified as an important pro‐inflammatory cytokine that is highly expressed in patients with diabetes, as well as in

  • vidal f. de la cruz inventions, patents and patent

    Vidal F. De La Cruz Inventions, Patents and Patent

    Vidal F. De La Cruz has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • vidal f. de la cruz inventions, patents and patent

    Vidal F. De La Cruz Inventions, Patents and Patent

    Method of treatment and bioassay involving macrophage migration inhibitory factor (MIF) as cardiac-derived myocardial depressant factor

  • high glucose induces apoptosis in ac16 human

    High glucose induces apoptosis in AC16 human

    How MIF modulates JNK activation in diabetic cardiovascular complications merits further investigation (particularly in diabetic cardiomyopathy). In conclusion, cardiac MIF and JNK pathways were found to be involved in the regulation of cardiac apoptosis induced by exposure of AC16 human cardiomyocytes to a high glucose concentration.

  • macrophage migration inhibitory factor in myocardial

    Macrophage migration inhibitory factor in myocardial

    May 01, 2014· Acute myocardial infarction (AMI) remains one of the leading causes of death in the developed world. There is emerging evidence that the cytokine macrophage migration inhibitory factor (MIF) is a crucial player in AMI.

  • myocardial depressant factor

    Myocardial depressant factor

    Myocardial depressant factor (MDF) or Myocardial Toxic factor (MTF) is a low-molecular-weight peptide released from the pancreas into the blood in mammals during various shock states.. MDF is a significant mediator of shock pathophysiology, reducing myocardial contractility, constricting splanchnic arteries and impairing phagocytosis by the reticuloendothelial system.

  • curriculum vitae - utsouthwestern.edu

    Curriculum vitae - utsouthwestern.edu

    June 2002 Macrophage Migration Inhibitory Factor (MIF) is a Novel Cardiac-derived Myocardial Depressant Factor American Shock Society Annual Meeting; Big Sky, Montana Regional/Local June 2002 Airway and Lung Development, Control of Breathing, and Apnea Syndromes University of Texas at Arlington Pediatric Acute Care Nurse Practitioner Program

  • myocardial depression in sepsis and septic shock

    Myocardial Depression in Sepsis and Septic Shock

    Myocardial dysfunction is an important component in the hemodynamic collapse induced by sepsis and septic shock. A series of inflammatory cascades triggered by the inciting infection generate circulatory myocardial depressant substances, including TNF-α, IL-1β, PAF and lysozyme.

  • macrophage inhibitory factor and high-mobility group-1

    Macrophage Inhibitory Factor and High-Mobility Group-1

    Cardiac tissue, removed as a planned part of the procedure, will be obtained from the cardiothoracic surgeons and assayed for MIF and for apoptosis, a potential mechanism of myocardial dysfunction mediated by MIF and/or HMG-1. The patient will be admitted to the cardiac intensive care unit post operatively for routine care.

  • high postoperative blood levels of macrophage migration

    High Postoperative Blood Levels of Macrophage Migration

    Macrophage migration inhibitory factor (MIF) is an inflammatory cytokine that exerts protective effects during myocardial ischemia/reperfusion injury.

  • myocardial depressant factor in cardiogenic shock

    Myocardial depressant factor in cardiogenic shock

    Myocardial depressant factor in cardiogenic shock A myocardial depressant factor (MDF) was discovered 1966 in the plasma of cats in postoligemic shock.1 Since that time, extensive studies have been carried out by Lefer and co- workers2 for validation of MDF as a shock factor.

  • curriculum vitae - utsouthwestern.edu

    Curriculum vitae - utsouthwestern.edu

    2001-2003 Title of Project: Macrophage Migration Inhibitory Factor (MIF) is a Cardiac-derived Myocardial Depressant Factor Role (Principal Investigator, Co-Investigator): PI Teaching Activities Committees concerned with medical and graduate student education 2003 Member, Department of Pediatrics Committee of Medical Student Education

  • endotoxin-induced myocardial dysfunction

    Endotoxin-Induced Myocardial Dysfunction

    migration inhibitory factor (MIF) has recently been identified as a cardiac-derived myocardial depressant factor in septic shock. Putative mechanisms by which MIF affects cardiac function are unknown.

  • macrophage migration inhibitory factor (mif): mechanisms

    Macrophage migration inhibitory factor (MIF): mechanisms

    Macrophage migration inhibitory factor is a cardiac-derived myocardial depressant factor. Am J Physiol Heart Circ Physiol 285: H2500-2509, 2003. 27. Giroir BP, Horton JW, White DJ, McIntyre KL, and Lin CQ. Inhibition of tumor necrosis factor prevents myocardial dysfunction during burn shock. Am J Physiol 267: H118-124, 1994. 31 28.

  • expressions of macrophage migration inhibitory factor in

    Expressions of macrophage migration inhibitory factor in

    Macrophage migration inhibitory factor (MIF) promotes inflammation and is an important factor in uremic cardiomyopathy. Aims: The aim of this study is to investigate the effects of serum macrophage MIF on myocardial hypertrophy in ESRD patients and to examine the relation of this factor to clinical characteristics. Settings and Design: One

  • sepsis-induced myocardial dysfunction: pathophysiology and

    Sepsis-induced myocardial dysfunction: pathophysiology and

    A myocardial depressant factor (MDF) was discovered in an experimental animal model of hemorrhagic shock during 1947 . The MDF determined in the blood of dogs during induced endotoxic shock seemed to be an 800–1000 dalton peptide that originated in the pancreas [ 46 ].

  • clinical review: myocardial depression in sepsis and

    Clinical review: Myocardial depression in sepsis and

    Myocardial dysfunction frequently accompanies severe sepsis and septic shock. Whereas myocardial depression was previously considered a preterminal event, it is now clear that cardiac dysfunction as evidenced by biventricular dilatation and reduced ejection fraction is present in most patients with severe sepsis and septic shock. Myocardial depression exists despite a fluid

  • biomed research international - hindawi publishing corporation

    BioMed Research International - Hindawi Publishing Corporation

    BioMed Research International is a peer-reviewed, Open Access journal that publishes original research articles, review articles, and clinical studies covering a wide range of subjects in life sciences and medicine. The journal is divided into 55 subject areas.

  • macrophage inhibitory factor and high-mobility group-1

    Macrophage Inhibitory Factor and High-Mobility Group-1

    Introduction: In recent scientific literature, 2 proteins, macrophage migration inhibitory factor (MIF) and high-mobility group-1 protein (HMG-1), have emerged as important mediators of inflammation and sepsis. Hypothesis: MIF and HMG-1 will be present in

  • macrophage migration inhibitory factor (mif) in

    MACROPHAGE MIGRATION INHIBITORY FACTOR (MIF) IN

    MACROPHAGE MIGRATION INHIBITORY FACTOR (MIF) Willis MS, Carlson DL, DiMaio JM, White MD, White DJ, Horton JW, Giroir BP: Macrophage migration inhibitory factor is a cardiac-derived myocardial depressant factor. Am J Physiol Heart Circ Physiol 285:H2500-H2509, 2003.

  • expressions of macrophage migration inhibitory factor in

    Expressions of macrophage migration inhibitory factor in

    Macrophage migration inhibitory factor (MIF) promotes inflammation and is an important factor in uremic cardiomyopathy. Aims: The aim of this study is to investigate the effects of serum macrophage MIF on myocardial hypertrophy in ESRD patients and to examine the relation of this factor to clinical characteristics. Settings and Design: One hundred forty-four patients with chronic kidney disease

  • inhibition of mif bioactivity by rational design of

    Inhibition of MIF Bioactivity by Rational Design of

    Abstract: Macrophage migration inhibitory factor (MIF) is an important immunoregulatory molecule with a unique ability to suppress the anti-inflammatory effects of glucocorticoids. Although considered a cytokine, MIF possesses a three-dimensional structure and

  • are platelets a 'forgotten' source of sepsis-induced

    Are platelets a 'forgotten' source of sepsis-induced

    The mechanism of sepsis-induced cardiac failure was initially thought to be related to the presence of 'myocardial depressant' substances that directly alter heart function. Exosomes released by platelets and identified in the plasma are suggested to, at least partially, explain myocardial depression in sepsis. This hypothesis needs to be evaluated by clinical studies.

  • myocardial depression and septic shock 2019 | my

    Myocardial Depression And Septic Shock 2019 | My

    Myocardial depressant factor (MDF) or Myocardial Toxic factor (MTF) is a low- molecular-weight peptide released from the pancreas into the blood in mammals during various shock states. MDF is a significant mediator of shock pathophysiology, reducing myocardial contractility, constricting splanchnic arteries and impairing.

  • hemodynamic and cardiac contractile function during sepsis

    Hemodynamic and Cardiac Contractile Function During Sepsis

    36. Garner LB, Willis MS, Carlson DL, DiMiao JM, White MD, White DJ, Adams GA, Horton JW, Giroir BP. Macrophage migration inhibitory factor (MIF) is a cardiac-derived myocardial depressant factor. Am J Physiol Heart Circ Physiol Aug 28 [Epub ahead of print], 2003.

  • sepsis-induced myocardial dysfunction: pathophysiology and

    Sepsis-induced myocardial dysfunction: pathophysiology and

    A myocardial depressant factor (MDF) was discovered in an experimental animal model of hemorrhagic shock during 1947 . The MDF determined in the blood of dogs during induced endotoxic shock seemed to be an 800–1000 dalton peptide that originated in the pancreas [ 46 ].

  • macrophage inhibitory factor and high-mobility group-1

    Macrophage Inhibitory Factor and High-Mobility Group-1

    Introduction: In recent scientific literature, 2 proteins, macrophage migration inhibitory factor (MIF) and high-mobility group-1 protein (HMG-1), have emerged as important mediators of inflammation and sepsis. Hypothesis: MIF and HMG-1 will be present in

  • thyroxine is a potential endogenous antagonist of

    Thyroxine is a potential endogenous antagonist of

    May 17, 2011· (2003) Macrophage migration inhibitory factor is a cardiac-derived myocardial depressant factor. Am J Physiol Heart Circ Physiol 285: H2500 – 2509.

  • cardiac molecular signaling after burn trauma | journal of

    Cardiac Molecular Signaling After Burn Trauma | Journal of

    MIF was shown to function as a myocardial depressant. MIF is constitutively expressed by the myocardium and released upon lipopolysaccharide challenge. 18 Further work has shown that MIF is a significant contributor to endotoxin-induced myocardial Macrophage migration inhibitory factor is a cardiac-derived myocardial depressant factor.

  • myocardiac | definition of myocardiac by medical dictionary

    Myocardiac | definition of myocardiac by Medical dictionary

    myocardial infarction (MI) death of the cells of an area of the heart muscle as a result of oxygen deprivation, which in turn is caused by obstruction of the blood supply; commonly referred to as a “heart attack.” The myocardium receives its blood supply from the two large coronary arteries and their branches. Occlusion of one or more of these blood vessels (coronary occlusion) is one of